Hyaluronic Acid Injection
Nasolabial folds, hollow cheeks, the eye area, chin, and lips. Rather than just looking at the areas of concern, we examine facial features, bone structure, and changes in volume, and consider the area, layer, and amount to inject to suit each individual.
Rather than asking where to place a single syringe, we consider where support is needed and what should be adjusted for a natural, balanced result across the whole face.
What is important is not to decide on the product or number of syringes in advance, but to consider the necessary treatment according to each person's condition. From the examination to the post-injection process, we focus on the following six points.
Choose a formulation that suits the injection site, layer, and purpose, taking into account the differences in hardness and blending.
We will examine your entire face and clearly explain the priority areas, proposed amount, and rationale for treatment before the treatment.
Candidacy for areas such as the forehead and around the eyes is assessed carefully because of their anatomy and risk profile.
During the treatment, we will share the condition with you in the mirror and make small adjustments as necessary.
We will explain not only the immediate changes, but also the time required for swelling to settle and when to consider additional injections.
We explain in advance that the duration, finish, and downtime will vary from person to person.
Two consecutive years at the top in the Kobe area for clinic deliveries of the Juvéderm series: 2024 and 2025, measured from January 1 through December 31, based on manufacturer-compiled delivery data. Reasons stated: use of longer-lasting products such as Voluma and Volux; the director clearly explains the required areas and number of syringes; extensive experience with technically demanding areas such as the forehead and around the eyes; patients can check progress in a mirror during injection; a natural change is visible immediately after injection and may be maintained for more than one year before reinjection; and the clinic carefully explains individual variation in effect and downtime as well as risks. Product image: Juvéderm Vista Voluma XC, 2 × 1.0 mL. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
Are you concerned about changes in volume due to age or the natural contour balance?
Nasolabial folds and shadows around the mouth are getting deeper
My cheeks or temples look hollow.
Hollows or shadows under my eyes are a concern.
I want to adjust the unevenness and roundness of my forehead
I would like to refine my chin and jawline.
I would like to discuss the shape of my lips and lip contours.
Package and syringe labeling: Juvéderm Vista VOLUMA XC, injectable gel with lidocaine, two 1.0 mL syringes; product codes visible include 30354, VB20, and 453813A10; manufacturer: Allergan.
Even for the same nasolabial folds, the treatment required will differ depending on the cheek support, bone structure, and the location of the skin and fat. During the examination, we will check the front, diagonal, and profile views and consider whether hyaluronic acid is suitable or whether to combine other treatments.
This is a treatment in which hyaluronic acid gel is injected into an appropriate soft-tissue plane or above the periosteum to physically correct the lost volume and contour of the face. While it is easy to see changes immediately after the procedure, it may take some time for the finish to stabilize due to swelling or bruising.
At our clinic, we use the JUVÉDERM VISTA series approved by the Ministry of Health, Labor and Welfare. Each product differs in firmness and tissue integration, and is selected according to the area, layer, and purpose of injection.
If we compare the structure of the face to a tent, the skeleton functions as a pole that supports the entire body, the skin and subcutaneous tissues serve as fabric, and the fibrous retaining structures act like ropes to keep the fabric taut.
Three labels identify the support concept: skeletal support; skin and subcutaneous tissue; and “when support changes.” The diagram compares the face to a tent, showing how a change in the deep supporting framework affects the overlying soft tissue.
Just as the poles of a tent support the entire fabric from the inside, the skeleton of the face becomes the base that supports the skin and fat. Changes in the skeletal structure associated with aging are a contributing factor to noticeable depressions and shadows in areas such as the temples, under the eyes, and cheeks.
Like the fabric of a tent and the ropes that keep it tensioned, the skin, subcutaneous tissues, and fibrous support structures support the surface of the face. When changes in firmness and support overlap, they can appear as nasolabial folds, shadows around the mouth, and a less defined jawline.
If the poles lose height or the ropes lose tension, the tent fabric will sag. Since skeletal support and surface changes overlap in the face, we assess which structural change contributes most.
Hyaluronic acid is an option to compensate for insufficient volume and skeletal support. On the other hand, if the goal is to tighten or firm the skin, device treatments such as HIFU and RF may be candidates. Consider combinations as necessary.
Reference:Aging changes in the midfacial skeleton of East Asians, Anatomical study of midface soft tissue spaces and supporting structures
Priorities are determined from overall facial balance, not from one isolated area.
By supplementing lost support, shadows and contour irregularities are made less noticeable. Check not only the front view but also the connection with the cheekbone area when viewed from an angle.
Instead of injecting only into the groove, we also examine the support of the midface and the balance of the mouth. Distribute small amounts to multiple areas as needed.
This area has thin skin and requires special consideration for blood vessels and nerves. Check the depression, fat, and cheek height to carefully determine suitability.
Filler may refine the chin and lower jawline to improve balance with the profile and mouth. If sagging is the main problem, device treatment may be appropriate.
Assess contour irregularity and skeletal support and consider continuity with the upper half of the face. Careful judgment is required as there is a possibility of serious complications such as incorrect injection into a blood vessel.
In addition to changing the size, we also adjust the amount while looking at the left-right difference, outline, and harmony with the entire face. We will share your desired shape before the treatment.
Check changes in bone structure, left-right differences, shadows, and volume in front, diagonal, and profile views. We discuss and plan where the limited amount should be allocated in a way that looks natural.
The required formulation and injection layer are different depending on the area areas requiring soft tissue integration and areas requiring structural contour support. Choose the one that suits your condition from the JUVÉDERM VISTA series.
Three Juvéderm Vista products are shown from left to right: VOLBELLA XC, VOLIFT XC, and VOLUMA XC. Each package contains two 1.0 mL syringes of injectable gel with lidocaine; the Japanese lines repeat the three product names.
We will take a record photo before the treatment and share the design. During the treatment, we will check your condition and make adjustments, and explain the precautions to take after the injection and any symptoms that require a visit to the doctor.
Allergan Aesthetics 2025 Certificate of Appreciation, presented to Minato Motomachi Beauty and Plastic Surgery Clinic and Dr. Nie. The certificate states that AbbVie / Allergan Aesthetics provides healthcare professionals with information and training needed for appropriate patient treatment and education, and recognizes contributions through one or more roles: chair, speaker, or instructor at professional seminars or internal training; chair, speaker, or trainer at injection seminars and other external events; supervision or interview participation for Allergan Beauty website content and articles or booklets for professionals and patients; or cooperation with public lectures and counseling experiences. Dated January 2026 and signed by Tetsuo Endo, President, AbbVie GK Allergan Aesthetics.
The director of our clinic was awarded the "2025 Certificate of Appreciation" by Allergan Aesthetics (AbbVie LLC).
This award was given in recognition of her contribution to the development of aesthetic medicine by serving as a chairperson, speaker, and trainer at seminars for medical professionals, academic conferences, and external events aimed at disseminating accurate knowledge and techniques regarding aesthetic medicine.
*This award relates to the achievements of medical professionals and does not guarantee the effectiveness or safety of the treatment.Based on actual cases, we introduce the concept of injection site and distribution.
Scroll horizontally to see 15 cases
Case title: “Our clinic’s hyaluronic acid result maintained at 1.5 years.” Photographs are labeled Before and After (1.5 years later). Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
We will explain the individual differences in the amount of filler remaining and the concept of additional injection.
Read the case column
Case title: “Lift the corners of the mouth with hyaluronic acid.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
Consider the shadow on the side of the mouth corner and the support of the lower face together.
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Case title: “Natural customized hyaluronic acid.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
Balance not only the lines but also the midface and chin.
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Case title: “Customized hyaluronic acid.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
The case describes the distribution of Voluma 2cc and VOLUX 2cc.
Read the case column
Case title: “Customized hyaluronic acid.” The comparison is labeled “2 years earlier” → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
The article explains long-term maintenance and readjustment.
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Case title: “Customized hyaluronic acid.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
Explains lack of support and face line design.
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Case title: “Customized hyaluronic acid.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
The case describes the distribution of 3 Voluma and 2 VOLUX.
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Case title: “Customized hyaluronic acid.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
This is an injection design that takes into account the support of the middle and lower face.
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Case title: “Combined HIFU and hyaluronic acid treatment.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
We will explain the treatment sequence to supplement support after tightening.
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Case title: “Hyaluronic acid for a more balanced jawline.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
Look at the contour from the shadow under the cheeks and the connection with the mouth.
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Case title: “Total facial treatment.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
The injection design takes into account the center of gravity of the face and the reflection of light.
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Case title: “Popular hyaluronic acid treatment for men.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
Addresses a tired or shadowed appearance while maintaining skeletal structure.
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Case title: “Natural rejuvenation treatment that makes a subtle difference.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
We will summarize the roles of hyaluronic acid, blepharoptosis surgery, and skin treatment.
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Case title: “Forehead hyaluronic acid filler.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
The article explains allocating volume to the front forehead.
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Case title: “Hyaluronic acid filler for a rounded forehead.” Photographs are ordered Before → After. Clinic credit: Minato Motomachi Beauty and Plastic Surgery Clinic / NIE CLINIC.
The case reviews the unevenness and lack of volume in the upper face.
Read the case column*Case photos do not guarantee treatment results. There are individual differences in the amount required, progress, and results.
We will discuss the injection plan for the entire face and your budget, and then suggest the number of syringes proposed.
*The displayed price includes tax. The indication, formulation, and injection amount are determined by examination. Prices must be checked against the current price list at the time of publication.
We will confirm your concerns, treatment history, medical history, and desired changes to determine whether hyaluronic acid injections are appropriate.
Take pictures of the front, diagonal, and profile, and share the injection site and amount plan in the mirror.
Select the needle or cannula according to the site and inject while checking the condition.
Check the condition after injection and make minor adjustments if necessary. The appearance on the day may differ from the final result due to swelling.
We will explain how to spend your time and the symptoms that require emergency medical attention. If you have any concerns, please contact us as soon as possible.
Pain, redness, swelling, tenderness, bruising, side-to-side difference, unevenness, discomfort, allergies, infection, and lumps may occur.
Incorrect injection or pressure into blood vessels may cause vascular occlusion, skin damage/necrosis, visual impairment, blindness, cerebral infarction, etc.
Please refrain from drinking alcohol, strenuous exercise, and bathing for a long time on the day of treatment. Do not press or rub the injection site.
If you experience severe pain, white or purple skin, mottled or reticular discoloration, worsening swelling, abnormal vision, or a strong headache, please contact our clinic immediately.
The package insert warns that hyaluronic acid preparations should not be injected into blood vessels, and that they should be used with particular caution around the eyes, between the eyebrows, and on the forehead.
See the package insert for PMDA “JUVÉDERM VISTA VOLUMA XC”If the injection site or amount does not match your facial features, it may look unnatural. At our clinic, we examine not only the areas of concern but also the support and balance of the entire face, and adjust the necessary amount in consultation with you. There are individual differences in the finish.
The duration varies depending on the preparation, injection site, injection amount, constitution, lifestyle, etc. We will explain the preparations used during the consultation and the expected course.
The injection is painful. The procedure is performed using a thin needle and local anesthesia, taking into account pain and bleeding. There are individual differences in how it feels.
Swelling, redness, pain, tenderness, and bruising may occur. Bruising often subsides in about a week, but the course varies from person to person.
Please refrain from drinking alcohol, strenuous exercise, and bathing for a long time on the day of treatment. If you experience severe pain, skin discoloration, worsening swelling, or abnormal vision, please contact our clinic immediately.
Depending on the situation, dissolution with hyaluronidase may be considered. The suitability, effectiveness, and risks of allergies will be determined after a medical examination.
Even if you are not sure how many syringes may be appropriate or are worried that it will look unnatural, please let us know what changes you would like to see and what results you would like to avoid. We will advise you on whether hyaluronic acid is suitable or whether you should prioritize another treatment.
